منابع مشابه
Out of Balance: R-loops in Human Disease
R-loops are cellular structures composed of an RNA/DNA hybrid, which is formed when the RNA hybridises to a complementary DNA strand and a displaced single-stranded DNA. R-loops have been detected in various organisms from bacteria to mammals and play crucial roles in regulating gene expression, DNA and histone modifications, immunoglobulin class switch recombination, DNA replication, and genom...
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Grasses are the single most important plant family in agriculture. In the past years, comparative genetic mapping has revealed conserved gene order (colinearity) among many grass species. Recently, the first studies at gene level have demonstrated that microcolinearity of genes is less conserved: small scale rearrangements and deletions complicate the microcolinearity between closely related sp...
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Vertebrate Hox genes are activated in a spatiotemporal sequence that reflects their clustered organization. While this colinear relationship is a property of most metazoans with an anterior to posterior polarity, the underlying molecular mechanisms are unknown. Previous work suggested that Hox genes were made progressively available for transcription in the course of gastrulation, implying the ...
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Polyketides are widespread, biologically active heteropolymers assembled by complexes of modular polyketide synthase(PKS) proteins. We implement a model of this system and explore its evolutionary behavior while subject to recombination in a changing environment. Under appropriate population parameters the combinatorial exploration of novelty allows a finite population to maintain high fitness ...
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During mammalian fetal development, axial structures acquire their specifications through the action of the Hox gene family of transcription factors (for review, see Krumlauf 1994). These are 39 such genes that are responsible for giving spatially restricted cues in a variety of embryonic derivatives, from the neural tube to the intestinal tract. In presomitic mesoderm, for example, level-speci...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2004
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2004.05.016